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HA001 - Hatton
Área: 2 - Terapia endodôntica

Apresentação: 04/09 - Horário: 08h30 às 17h30 - Local: Salão Cinza

Biocompatibility and biomineralization of different formulations of F18 bioglass in furcation defects in Wistar rats
Pedro Henrique Chaves de Oliveira , Mylena Fernanda de Oliveira Santos, Mariana Pagliusi Justo, Flávio Duarte Faria, Juliana Goto, Marcos Berti Jacomine, Edilson Ervolino, Luciano Tavares Angelo Cintra
Odontologia Restauradora UNIVERSIDADE ESTADUAL PAULISTA - ARAÇATUBA
Conflito de interesse: Não há conflito de interesse

This study evaluated the biocompatibility and biomineralization of different formulations of the bioglass F18 in furcation defects of Wistar rats. The furcations of the 1st and 2nd upper right molars of 40 rats were accessed, irrigated with saline solution and, after the bleeding be controlled, they were sealed with one of the following materials: Gutta-percha (control), Mineral Trioxide Aggregate (MTA), cobalt-doped F18 (F18+Co) and F18 in consistent form (F18 Putty). After 7 and 30 days (n=10/group/period), the animals were euthanized, the maxillae removed and processed for H&E staining, PSR and immunohistochemistry for OCN and OPN. Statistical tests were applied (p<0.05). At 7 days, the control group presented mild to moderate inflammation, while F18+Co presented severe inflammation (p<0.05). MTA presented moderate to severe inflammation and F18 Putty moderate inflammation, with no difference for F18+Co and control (p>0.05). At 30 days, there were no differences between the groups regarding inflammation (p>0.05). At 7 days, F18 Putty presented a greater amount of immature fibers and a smaller number of mature fibers compared to the other groups (p<0.05). At 30 days, MTA presented more immature fibers and less mature fibers compared to the other groups (p<0.05). For OCN and OPN, the MTA, F18+Co and F18 Putty groups showed higher immunolabeling compared to the control at 7 days (p<0.05). At 30 days, only MTA and F18+Co were different from the control (p<0.05).

It is concluded that bioglasses and MTA have biocompatibility and contribute to tissue repair. In addition, MTA and F18+Co have greater stimulation of biomineralization compared to F18 Putty.

(Apoio: FAPs - FAPESP N° 2021/04343-6)

HA002 - Hatton
Área: 2 - Terapia endodôntica

Apresentação: 04/09 - Horário: 08h30 às 17h30 - Local: Salão Cinza

Blood clot influence on tooth discoloration in endodontic regenerative procedures
Rodolfo Figueiredo de Almeida, Roberta Caroline Bruschi Alonso, Arian Braido, Paulo Henrique Gabriel, Marina Angélica Marciano, Talita Tartari, Brenda Paula Figueiredo de Almeida Gomes, Adriana de Jesus Soares
Endodontia FACULDADE DE ODONTOLOGIA DE PIRACICABA
Conflito de interesse: Não há conflito de interesse

This study aimed to evaluate the influence of the blood clot scaffold on the tooth discoloration in teeth treated with regenerative endodontic procedures, and its correlation with different cervical barrier materials. Sixty bovine teeth were prepared to simulate immature open apex conditions and were randomly assigned to two scaffold groups: blood plus agar and pure agar. The following cervical barrier materials were tested: MTA HP Angelus, Biodentine, EndoSeal MTA, SFS (Calcium hydroxide, zinc oxide and chlorhexidine gel) and Coltosol. Color changes were assessed using a digital spectrophotometer at three time points: T0 (baseline), T1 (one day after treatment) and T90 (90 days after treatment). Discoloration was measured using the ΔE₀₀ formula (CIEDE2000): ΔE₀₀ < 1.8 = imperceptible; 1.8-3.3 = acceptable; > 3.3 = unacceptable. Between T0 and T1, all groups using the blood plus agar scaffold showed a greater tendency toward discoloration (higher ΔE₀₀ values), except for the Biodentine group (ΔE₀₀ = 2.07). The most notable color changes were observed in the Coltosol (ΔE₀₀ = 4.89), MTA HP Angelus (ΔE₀₀ = 4.29), and SFS (ΔE₀₀ = 4.25) groups. At T90, ΔE₀₀ values were generally lower than at T1, suggesting a potential reduction in discoloration over time. A significant effect was found for the factor "time" (p = 0.016), indicating an overall decrease in discoloration from T1 to T90.

These results highlight the importance of selecting appropriate materials in regenerative endodontic procedures, as clinically relevant discoloration may occur even in the absence of statistical significance, probably due to the blood clot formation.

(Apoio: CAPES N° 001)

HA003 - Hatton
Área: 3 - Cariologia / Tecido Mineralizado

Apresentação: 04/09 - Horário: 08h30 às 17h30 - Local: Salão Cinza

Comparative Performance of AI-Based Algorithms for Caries Detection in Dentistry
Eduardo Trota Chaves, Vitor Henrique Digmayer Romero, Niels Van Nistelrooij, Shankeeth Vinayahalingam, Fausto Medeiros Mendes, Maximiliano Sérgio Cenci, Marie-Charlotte DNJM Huysmans, Giana da Silveira Lima
Odontologia UNIVERSIDADE FEDERAL DE PELOTAS
Conflito de interesse: Não há conflito de interesse

This study compared the diagnostic performance of commercial (Second Opinion®, Diagnocat®, CranioCatch®) and experimental models, for the detection of caries lesions in bitewings. Research-based models consisted in mask architectures, independently trained with different datasets, developed at the Radboud AI Lab. Occlusal and proximal surfaces of set of 200 bitewings were manually annotated by a cariology expert, forming the referential for comparisons. Accuracy in detecting Global Caries (GC), Secondary Caries (SC), and Dentin Lesions-only (DL) were calculated per surface. Second Opinion® was consistently the highest sensitivity across all analyses (GC: 93.0%; SC: 83.5%; DL: 89.6%), with corresponding AUCs up to 0.91. In contrast, Diagnocat® presented a more balanced profile, combining moderate-to-high sensitivity with strong specificity (SC: 95.1%; DL: 97.9%; AUCs 0.78-0.87). CranioCatch® achieved the highest specificity among the commercial models-especially for DL (98.5%)-but this came at the expense of sensitivity, which remained below 53%. The experimental models were optimized to reduce false positives, maintaining specificities above 97% for SC and up to 98.7% for DL, though with more modest sensitivities (65-75%) and AUCs between 0.75 and 0.85.

While lower sensitivity may lead to missed early-stage lesions, these are often slow-progressing and clinically manageable without immediate intervention. In contrast, false positives can prompt unnecessary restorative procedures and the irreversible removal of healthy tissue. These findings highlight the importance of model selection based on clinical context and support the integration of AI with professional judgment in caries detection.

(Apoio: CAPES N° 001 | CAPES N° 001 | CNPq N° 444911/2024-3)

HA004 - Hatton
Área: 3 - Cariologia / Tecido Mineralizado

Apresentação: 04/09 - Horário: 08h30 às 17h30 - Local: Salão Cinza

Crystallographic and mechanical modifications of human enamel following therapeutic radiation
Allyne Jorcelino Daloia de Carvalho, Slobodan Sirovica, Marina Guimarães Roscoe, Hui Lynn Ooi, Sagar P. Jadeja, Owen Addison, Veridiana Resende Novais
Dentística e Materiais Dentários UNIVERSIDADE FEDERAL DE UBERLÂNDIA
Conflito de interesse: Não há conflito de interesse

Radiation-related caries affects over 50% of head and neck cancer patients, and enamel structural changes remains poorly understood. This study aimed to correlate mechanical properties, solubility, and crystallographic enamel changes induced by radiotherapy with its proximity to the dentin-enamel junction (DEJ). Human third molars were sectioned for paired samples - non-irradiated (NI) and in vitro irradiated (IR) (60 Gy; n=8), and compared with ex-vivo irradiated teeth (n=6). Microhardness, indentation fracture toughness, and solubility tests were performed. Synchrotron Radiation X-ray Microdiffraction (S-µXRD) measurements were conducted at the Diamond Light Source (Oxford, UK). Statistical analyses were performed using paired or independent parametric tests (ɑ=0.05). For NI controls, microhardness decreased and indentation fracture toughness increased with proximity to the DEJ. Radiation reduced both properties for in-vitro samples (p<0.001), but the DEJ-related pattern was preserved. Citric acid caused no significant lesion depth change (p=0.392) while lactic acid increased depth in IR specimens (p<0.001). Mechanical properties reduction and increased solubility were exacerbated in ex-vivo samples. S-µXRD analysis revealed notable alterations in enamel crystallites at the unit-cell level post-radiation, including dimensional changes in the a = b and c-axis lengths. Multiple crystallite populations with two principal orientations were identified, with distinct patterns emerging near the DEJ, suggesting that residual strain impacts are not uniformly distributed.

These crystallographic modifications suggest irreversible effects on the enamel structure likely leading to increased caries risk.

(Apoio: CAPES N° 001 | FAPs - FAPEMIG | CNPq)

HA005 - Hatton
Área: 3 - Controle de infecção / Microbiologia / Imunologia

Apresentação: 04/09 - Horário: 08h30 às 17h30 - Local: Salão Cinza

Unveiling Proteomic Profiles of Protein-aPDT Synergistic Effects: Targeting Resistant Mixed Biofilms
Luana Mendonça Dias , Ana Cláudia Pavarina, Walter Siqueira
UNIVERSIDADE ESTADUAL PAULISTA - ARARAQUARA
Conflito de interesse: Não há conflito de interesse

This study aimed to evaluate proteomic alterations in the Extracelullar Matrix (ECM) of Candida albicans and Streptococcus mutans mixed biofilms treated with salivary proteins Histatin 3 (His3) or Histatin 5 (His5) followed by antimicrobial photodynamic therapy (aPDT), using a 3D oral epithelium model. Reconstructed human oral epithelium (EpiSkin) composed of differentiated oral keratinocytes was pre-treated with His3 or His5 (512 μM; 2 h; 37 °C; 10% CO₂), then infected with polyene-resistant C. albicans (0.74 ± 0.03 × 10⁷ CFU/mL) and S. mutans (0.63 ± 0.08 × 10⁹ CFU/mL). After 24 h of biofilm growth (37 °C; 10% CO₂; 70 rpm), aPDT was applied using Photodithazine (200 mg/L) and red LED light (660 nm; 50 J/cm²). Epithelium models with and without infection were used as positive and negative controls. ECM proteins were extracted, quantified (BCA assay), concentrated (C18 ZipTips), digested (Trypsin), and analyzed by nano-LC-MS/MS. Data underwent clustering, Principal Component Analysis (PCA), Gene Ontology (GO), STRING, and KEGG/iPath analysis (n=9/group). Significance was set at p<0.05. BCA showed the greatest ECM protein reduction in His3+aPDT (67%), followed by His5+aPDT (40%). His5+aPDT promoted significative downregulation of proteins linked to ribosomes and nuclear transport. GO revealed suppression of RNA localization; STRING showed a dense network (60 nodes, 414 edges, p<1.0e-16). KEGG indicated enriched nucleocytoplasmic transport (FDR=1.6e-6), while iPath mapping showed activity in purine/pyrimidine and riboflavin metabolism-suggesting stress adaptation mechanisms.

His3 and His5 with aPDT disrupted ECM and remodeled protein networks, reinforcing their potential against resistant mixed biofilms.

HA006 - Hatton
Área: 3 - Controle de infecção / Microbiologia / Imunologia

Apresentação: 04/09 - Horário: 08h30 às 17h30 - Local: Salão Cinza

Distinct microbial signatures in oral and fecal microbiota across different periodontal clinical conditions
Adriana Miranda de Oliveira, Talita Gomes Baêta Lourenço, Flávia Aparecida Chaves Furlaneto, Michel Reis Messora, Marcella Costa Ribeiro, Egija Zaura, Bernd W. Brandt, Ana Paula Vieira Colombo
Instituto de Microbiologia Paulo de Góes UNIVERSIDADE FEDERAL DO RIO DE JANEIRO
Conflito de interesse: Não há conflito de interesse

This study investigated microbial signatures associated with periodontal clinical conditions by analyzing integrated dental plaque and fecal 16S rRNA sequencing datasets from six independent studies. After centered log-ratio transformation and batch correction, Random Forest classifiers were trained on combined plaque and fecal datasets, with additional batch-stratified models used to explore technical influences. In plaque samples, species such as Mogibacterium timidum, Pseudoramibacter alactolyticus, and Aggregatibacter actinomycetemcomitans were associated with periodontitis, while Actinomyces spp. and Veillonella spp. were related with periodontal health. In fecal samples, gingivitis was associated with Fusicatenibacter, Blautia, Ligilactobacillus, Lachnospiraceae [Eubacterium] hallii, and Dorea, whereas health was associated with Eggerthellaceae, Enterococcus, and Ruminoclostridium. For periodontitis, members of the Lachnospiraceae family were identified among the most important taxa. A notable finding was the detection of oral-associated genera (Fusobacterium, Streptococcus, Treponema) in the fecal microbiota of gingivitis patients within one sequencing batch, suggesting a potential oral-gut microbial overlap in this clinical condition. These results demonstrate the feasibility of identifying compartment-specific microbial biomarkers for periodontal diagnosis, while highlighting the complexity introduced by technical variation.

Our findings support the identification of microbial signatures of periodontal status across heterogeneous datasets and highlight the need for standardized taxonomy and batch-aware pipelines in multi-study microbiome analyses.

(Apoio: CNPq N° 140571/2021-3 | CAPES N° 88887.892358/2023-00 | FAPs - FAPERJ N° E-26/202.255/2019 PDJ10)

HA007 - Hatton
Área: 4 - Odontopediatria

Apresentação: 04/09 - Horário: 08h30 às 17h30 - Local: Salão Cinza

Validation of the diagnosis of hypomineralization characterized by demarcated opacity by intraoral scanner: in-vitro and in-vivo study
Bruna Cordeiro Amarante, Giovanna Bueno Marinho, Tron Darvann, Stavroula Michou, Victor Elias Arana-Chavez, Gabriela sá, Nuno Vibe Hermann, Marcelo Bönecker
Odontopediatria e Ortodontia UNIVERSIDADE DE SÃO PAULO - SÃO PAULO
Conflito de interesse: Não há conflito de interesse

Enamel hypomineralization is prevalent in pediatric dentistry, but its diagnosis remains challenging. This in-vitro and in-vivo study aimed to validate the diagnosis of hypomineralization (demarcated opacities) in primary and permanent teeth using an intraoral scanner, applying the MIH index (Ghanim et al., 2019). In-vitro phase: 47 molars (16 primary, 31 permanent) evaluated by i) visual-tactile diagnosis, ii) photography, iii) intraoral scanning, iv) MicroCT and v) scanning electron microscopy (SEM). Data collection included: opacity color (exam), 3D color and fluorescence (scanner), grayscale (MicroCT), and qualitative analysis (SEM). MicroCT and SEM revealed structural differences between hypomineralized and healthy enamel, increased porosity and reduced mineral density in affected regions. SEM indicated irregular enamel prisms and greater bacterial presence in affected areas. Opacity color was correlated with porosity; lighter shades were less porous than darker ones. In-vivo phase: 146 patients with hypomineralized primary and permanent teeth were examined by i) visual-tactile diagnosis, ii) intraoral scanning. Accuracy was evaluated comparing the exams performed in patients with ones performed in 3D models. For permanent teeth, accuracy was 0.99 (examiner 1) and 0.98 (examiner 2); for primary teeth, accuracy was 0.97. Fluorescence analysis revealed distinct porosity-related color variation in-vivo and in-vitro.

In conclusion, intraoral scanners effectively reproduce true opacity color, while fluorescence aids in porosity assessment, although caution is advised when interpreting opacity lesions. Findings of the in-vivo study were found to be consistent with those obtained from the in-vitro analysis

(Apoio: CAPES N° 88887.936640/2024-00 | CAPES N° 88887.877593/2023-00)

HA008 - Hatton
Área: 4 - Ortodontia

Apresentação: 04/09 - Horário: 08h30 às 17h30 - Local: Salão Cinza

Perceived Orthodontic Treatment Need, Dental Aesthetic Satisfaction, and Social Media Influence: A Comparison between Brazil and Finland
Gil Guilherme Gasparello, Anna-sofia Silvola, Krista Hylkilä, Matheus Melo Pithon, Orlando Motohiro Tanaka
PPGO PONTIFÍCIA UNIVERSIDADE CATÓLICA DO PARANÁ
Conflito de interesse: Não há conflito de interesse

This study aimed to compare the perception of orthodontic treatment need, satisfaction with dental aesthetics, and the influence of social media between populations in Brazil and Finland. A total of 730 participants (365 from each country) completed a questionnaire. The mean age was 26.89 ± 9.46 years (Finland: 27.03 ± 11.25; Brazil: 26.76 ± 7.25). Self-perceived orthodontic treatment need and satisfaction with dental aesthetics were assessed using a Visual Analogue Scale (VAS). Social media influence was investigated through questions adapted from the Social Media Use Scale (SMUS), covering time spent on social platforms, filter use, and appearance/lifestyle comparisons. Brazilians reported a significantly higher perceived need for orthodontic treatment (p < 0.001), although satisfaction with dental aesthetics did not differ significantly between groups (p = 0.438). Brazilians also reported more time on social media (p = 0.029), greater use of filters (p < 0.001), and more frequent appearance (p = 0.011) and lifestyle comparisons (p < 0.001). A negative correlation was found between treatment need perception and dental aesthetic satisfaction (r = -0.476). However, social media behaviors showed no or only weak correlations (r < 0.20) with perceived need of orthodontics treatment and dental aesthetics satisfaction.

Although social media use did not directly predict perceived orthodontic treatment need, the distinct patterns of engagement observed between Brazilian and Finnish participants suggest that cultural, psychosocial, and behavioral variables may play a mediating role in shaping aesthetic perceptions and treatment motivations

(Apoio: CAPES N° 88881.982386/2024-01)

HA009 - Hatton
Área: 4 - Ortodontia

Apresentação: 04/09 - Horário: 08h30 às 17h30 - Local: Salão Cinza

Orthodontic Treatment for Prominent Upper Front Teeth (Class II Division 1) in Children and Adolescents: A Cochrane Systematic Review
Deise Caldas Kuhlman, Flavia Artese, José Augusto Mendes Miguel, Catia Cardoso Abdo Quintão, Klaus Barretto Dos Santos Lopes Batista
UNIVERSIDADE DO ESTADO DO RIO DE JANEIRO
Conflito de interesse: Não há conflito de interesse

Prominent maxillary incisors affect 20- 25% of children and adolescents during tooth eruption, increasing risks of psychosocial issues and dental trauma, often requiring orthodontic referrals since self-correction is unlikely. This Cochrane systematic review update (CD003452) evaluates the effectiveness of orthodontic appliances for prominent upper anterior teeth in children and adolescents with Class II division 1 malocclusion, examining early (ages 7-11) and late (ages 12-16) interventions and comparing delayed treatment versus no treatment. A thorough search by a Cochrane Oral Health Information Specialist included databases such as CENTRAL, Ovid MEDLINE, Ovid Embase, and trial registries (WHO and clinicaltrials.gov) up to July 1, 2024, without language or date restrictions. Only randomized controlled trials investigating orthodontic interventions for Class II division 1 malocclusion were included. The search identified 1,434 studies, with 525 duplicates. After screening, 25 studies were selected (eight duplicates resulted in 17 eligible studies). Of the 17 studies, 10 used Twin Block appliances, three used headgear, two used Forsus appliances, and two used Carriere Motion appliances. Control groups included two Myofunctional appliance groups, one Hanks Herbst appliance, one Monoblock appliance, and one Frankel II appliance. Additionally, five studies reported on oral health and quality of life, while six indicated harm.

These preliminary results show that the Twin Block appliance is the most studied device, followed by Headgear. The findings also indicate active involvement in exploring new treatment alternatives and highlight patient perspectives in orthodontics care.

(Apoio: FAPERJ N° 310767)

HA010 - Hatton
Área: 4 - Ortodontia

Apresentação: 04/09 - Horário: 08h30 às 17h30 - Local: Salão Cinza

Analysis of the impact of artificial saliva on the sorption and translucency of resins used in directly printed orthodontic aligners
Gabriela Gonçalves Innocente, Tony Vieira Faria, Carolina Carmo de Menezes, Luana Paz Sampaio, Silvia A. S. Vedovello, João Roberto Gonçalves
UNIVERSIDADE ESTADUAL PAULISTA - ARARAQUARA
Conflito de interesse: Não há conflito de interesse

This study investigated the effect of artificial saliva on the translucency and sorption of resins used in the direct 3D printing of orthodontic aligners. A total of 36 specimens (n=18 per resin) were printed using SmartDent TA36 and Tera Harz TC-85 resins with a digital light processing (DLP) 3D printer. All specimens underwent standardized post-processing, including centrifugation and ultraviolet light curing in a controlled nitrogen atmosphere. The samples were immersed in artificial saliva at 37 ± 1°C for 7 and 14 days. Sorption was measured by mass variation using an analytical scale, and translucency was assessed through spectrophotometry by calculating the translucency parameter (∆TP). Statistical analysis was conducted using linear mixed models for repeated measures, followed by the Tukey-Kramer test (α=0.05). Both resins exhibited a significant increase in mass after 7 days of immersion (p<0.05), with no significant difference between them (p>0.05). This study compared the translucency and saliva sorption of SmartDent TA36 and Tera Harz TC-85 resins after immersion in artificial saliva for 7 and 14 days. No significant difference in saliva sorption (p<0.05) was observed between the resins, with both showing a more pronounced increase in mass during the first seven days(p>0.05). Initial translucency values were similar for both resins; however, SmartDent TA36 exhibited greater translucency stability than Tera Harz TC-85 (p<0.05) after 7 and 14 days of immersion.

It was concluded that SmartDent TA36 demonstrated superior optical stability over time, whereas both materials showed similar behavior in terms of saliva sorption.

(Apoio: CAPES)